2016-17 Cancer Network Annual Report

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Academic Publications

As our physicians collaborate to advance cancer care, they share their discoveries in leading medical journals. Here we share their recent work:

Assadipour, Y., Azoury, S.C., Schaub, N.N., Hong, Y., Eil, R., Inchauste, S.M., Steinberg, S.M., Venkatesan, A.M., Libutti, S.K., & Hughes, M.S. (2016). Significance of preoperative radiographic pancreatic density in predicting pancreatic fistula after surgery for pancreatic neuroendocrine tumors. American Journal of Surgery, 212(1), 40-6. doi: 10.1016/j. amjsurg.2015.07.031

Bagcivan, G., Bakitas, M., Dionne-Odom, J.N., Frost, J., Plunkett, M., Stephens, L.A., & Bishop, P. (2016) What’s in the ‘special sauce’ of protocol-driven outpatient palliative care consultations? Journal of Clinical Oncology, 34(26_suppl), 139. doi: 10.1200/ jco.2016.34.26_suppl.139

Bakitas, M., Dahlin, C. & Bishop, M.F. (2017) Palliative and End of Life Care. In Buttaro, T.M., Trybulski, J., Polger-Bailey, P., Sandberg-Cook, J. (eds), Primary Care: A Collaborative Practice, 5th Edition. Elsevier Mosby; p.94-108.

Bharadwaj, P., Helfen, K. M., Deleon, L. J., Thompson, D. M., Ward, J. R., Patterson, J., & Bleznak, A. D. (2016). Making the Case for Palliative Care at the System Level: Outcomes Data. Journal of Palliative Medicine, 19(3), 255-258. doi:10.1089/ jpm.2015.0234

Boughey, J., Ballman, K., Le-Petross, H., McCall, L., Mittendorf, E., Ahrendt, G., Wilke, L., Taback, B., Feliberti, E., & Hunt, K. (2016). Identification and resection of clipped node decreases the false-negative rate of sentinel lymph node surgery in patients presenting with node-positive breast cancer (T0–T4, N1–N2) who receive neoadjuvant chemotherapy: Results from ACOSOG Z1071 (Alliance). Annals of Surgery, 263(4), 802-807. doi: 10.1097/SLA.0000000000001375

Faivre, S., Niccoli, P., Castellano, D., Valle, J.W., Hammel, P., Raoul, J.L., Vinik, A., Van, C.E., Bang, Y.J., Lee, S.H., Borbath, I., Lombard-Bohas, C., Metrakos, P., Smith, D., Chen, J.S., Ruszniewski, P., Seitz, J.F., Patyna, S., Lu, D.R., Ishak, K.J., & Raymond, E. (2016). Sunitinib in pancreatic neuroendocrine tumors: Updated progression-free survival and final overall survival from a phase III randomized study. Annals of Oncology, 28(2), 339-343. doi: https://doi.org/10.1093/annonc/mdw561

Goff, S.L., Dudley, M.E., Citrin, D.E., Somerville, R.P., Wunderlich, J.R., Danforth, D.N., Zlott, D.A., Yang,Y.C., Sherry, R.M., Kammula, U.S., Klebenoff, C.A., Hughes, M.S., Restifo, N.P., Langhan, M.M., Shelton, T.E., Lu, L., Kwong, M.L., Ilyas, S., Klemen, N.D., Payabyab, E.D., Morton, K.E., Toomey, M.A., Steinberg, S.M., White, D.E., & Rosenberg, S.A. (2016). Randomized, prospective evaluation comparing intensity of lymphodepletion before adoptive transfer of tumor infiltrating lymphocytes for patients with metastatic melanoma. Journal of Clinical Oncology, 34(20); 2389-97. doi: 10.1200/ JCO.2016.66.7220

Hughes, M.S., Azoury, S.C., Assadipour, Y., Straughan, D.M., Trivedi, A.N., Lim, R.M., Joy, G., Voellinger, M.T., Tang, D.M., Venkatesan, A.M., Chen, C.C., Louie, A., Quezado, M.M., Forbes, J., & Wank, S.A. (2016). Prospective evaluation and treatment of familial carcinoid small intestine neuroendocrine tumors (SI-NETs). Surgery, 159 (1): 350-35. doi: 10.1016/j.surg.2015.05.041

Hughes, M.S., Zager, J., Faries, M., Alexander, H.R., Royal, R.E., Wood, B., Choi, J., McCluskey, K., Whitman, E., Agarwala, S., Siskin, G., Nutting, C., Toomey, M.A., Webb, C., Beresnev, T., & Pingpank, J.F. (2016). Results of a randomized controlled multi-center phase III trial of percutaneous hepatic perfusion compared to best available care for patients with melanoma liver metastases. Annals of Surgical Oncology, 23(4):1309-1319. doi: 10.1245/ s10434-015-4968-3

Klemen, N.D., Feingold, P.L., Goff, S.L., Hughes, M.S., Kammula, U.S.,Yang, J.C., Schrump, D.S., & Rosenberg, S.A. (2017). Metastasectomy following immunotherapy with adoptive cell transfer for patients with advanced melanoma. Annals of Surgical Oncology, 24(1), 135-141. doi: 10.1245/s10434-016- 5537-0

Lyons, R., Schneider, J., “Gallbladder carcinoma in Association with Ascaris lumbricoides Infection” Surgical Infections Case Reports 2017 2.1: 51-53

Mauldin, I.S., Wages, N.A., Stowman, A.M., Wang, E., Smolkin, M.E., Olson, W.C., Deacon, D.H., Smith, K.T., Galeassi, N.V., Chianese-Bullock, K.A., Dengel, L.T., Marincola, F.M., Petroni, G.R., Mullins, D.W., & Slingluff, C.L. Jr. (2016). Intratumoral interferon- gamma increases chemokine production but fails to increase T cell infiltration of human melanoma metastases. Cancer Immunology, Immunotherapy, 65(10):1189-99. doi: 10.1007/s00262-016-1881-y

Romano, A.M., Gade, K., Nielsen, G., Havard, R., Harrison, J., Barclay, J., Stukenborg, G., Read, P., Blackhall, L., & Dillon, P.M. (2017). Early palliative care reduces end-of-life ICU use but not ICU course in patients with advanced cancer. The Oncologist, 22(3), 318-323. doi: 10.1634/theoncologist. 2016-0227

Sei, Y., Feng, J., Zhao, X., Forbes, J., Tang, D., Nagashima, K., Hanson, J., Quezado, M.M., Hughes, M.S., & Wank, S.A. (2016). Polyclonal crypt genesis and development of familial small intestine neuroendocrine tumors. Gastroenterology, 151(1):140-151.

Thangjam, G., Birmpas, C., Barabutis, N., Gregory, B., Clemens, M., Newton, J., Fulton, D., & Catravas, J. (2016). Hsp90 inhibition suppresses NF-B transcriptional activation via Sirt-2 in human lung microvascular endothelial cells. American Journal of Physiology – Lung Cellular and Molecular Physiology, 310(10), L964-L974. doi: 10.1152/ajplung.00054.2016

Valente, S., Tendulkar, R., Cherian, S., O’Rourke C., Greif, J., Bailey, L., Uhl, V., Bethke, K., Donnelly, E., Rudolph, R., Pederson, A., Summer, T., Lottich, S., Ross, D., Laronga, C., Loftus, L., Abbott, A., Kelemen, P., Hermanto, U., Friedman, N., Bedi, G., Joh, J., Thompson III, W., Hoefer, R., Wilson, J., Kang, S., Rosen, B., Ruffer, J., Bravo, L., Police, A., Escallon, J., Fyles, A., McCready, D., Graves, G., Rohatgi, N., Eaker, J., Graves, J., Willey, S., Tousimis, E., Collins, B., Shaw, C., Riley, L., Deb, N., Kelly, T., Andolino, D., Boisvert, M., Lyons, J., Small Jr., W., & Grobmyer, S. (2016). TARGIT-R (Retrospective): North American experience with intraoperative radiation using low-kilovoltage X-rays for breast cancer. Annals of Surgical Oncology, 23(9), 2809-2815. doi: 10.1245/ s10434-016-5240-1

Vinik, A.I., Wolin, E.M., Liyanage, N., Gomez- Panzani, E., Fisher, G.A. (2016). Evaluation of lanreotide depot/autogel efficacy and safety as a carcinoid syndrome treatment (elect): A randomized, double-blind, placebo-controlled trial. Endocrine Practice, 22(9), 1068-1080. doi: 10.4158/EP151172.OR

Vinik, A.I., Chaya, C. (2016). Clinical presentation and diagnosis of neuroendocrine tumors. Hematology/ Oncology Clinics of North America, 30(1), 21-48. doi: 10.1016/j.hoc.2015.08.006

SA Valente, RD Tendulkar, S Cherian, C O’Rourke, JM Greif, L Bailey, V Uhl, KP Bethke, ED Donnelly, C Laronga, L Loftus, AM Abbott, P Kelemen, U Hermanto, NB Friedman, GC Bedi, JE Joh, WA Thompson, RA Hoefer, JP Wilson, SK Kang, B Rosen, J Ruffer, L Bravo, A Police, JM Escallon, AW Fyles, DR McCready, GM Graves, N Rohatgi, JA Eaker, J Graves, SC Wiley, EA Tousimis, BT Collins, CM Shaw, Lee Riley, N Deb, T Kelly, DL Andolina, ME Boisvert, J Lyons, W Small Jr, SR Grobmyer. TARGIT-R (Retrospective): North American Experience with Intraoperative Radiation Using Low-Kilovoltage X-Rays for Breast Cancer. Annals of Surgical Oncology Published online: 09 May 2016

Siewertsz van Reesema LL, Zheleva V, Winston JS, Jansen RJ, O’Connor CF, Isbell AJ, Bian M, Qin R, Bassett PT, Hinson VJ, Dorsch KA, Van Sciver RE, Tang-Tan AM, Harden EA, Chang DZ, Allen CA, Perry RR, Hoefer RA, Tang AH. SIAH and EGFR, two RAS pathway biomarkers, are highly prognostic in locally advanced and metastatic breast cancer. EBioMedicine. 11 (2016) 183-198.

Siewertsz van Reesema LL, Lee MP, Zheleva V, Winston JS, O’Connor CF, Perry RR, Hoefer RA, Tang AH. RAS pathway biomarkers for breast cancer prognosis. CLI-Online, 31/10/2016.

*Sentara Cancer Network contributors are shown in blue.